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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1975-12-11
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pubmed:abstractText |
Normal immunosuppressive protein (NIP) isolated from human plasma was studied in two well defined systems. (1) Spontaneous rosettes of sheep red blood cells with human peripheral blood lymphocytes and PHA-induced lymphocyte cytotoxicity as indicators for T-cell function. (2) Rosette formation tests of human lymphocytes with antibody-coated erythrocytes or erythrocytes coated with antibody and complement as well as antibody-induced lymphocyte-mediated cytotoxicity represented non-T-cell activity. While NIP did not inhibit the formation of any of the above mentioned rosettes, it practically prevented both PHA-induced and antibody-mediated lymphocyte cytotoxicity. Relatively small amounts of NIP inhibited PHA-induced cytotoxicity while higher doses were required for the inhibition of antibody-mediated lymphocyte cytotoxicity. Possible mechanisms of its suppressive activity are discussed. NIP was found to be heat-stable and did not show any species specificity, as NIP preparations from human plasma were immunosuppressive in human, mouse and guinea-pig systems.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-13634034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-13936400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4100691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4109226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4110803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4113793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4114255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4114496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4114972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4115705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4123372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4134062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4167453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4179930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4392749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4542160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4542262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4567307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4589210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4590767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4600483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-4809459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-5058234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/51828-5147490
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
433-43
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:51828-Alpha-Globulins,
pubmed-meshheading:51828-Animals,
pubmed-meshheading:51828-Antibodies,
pubmed-meshheading:51828-B-Lymphocytes,
pubmed-meshheading:51828-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:51828-Erythrocytes,
pubmed-meshheading:51828-Guinea Pigs,
pubmed-meshheading:51828-Humans,
pubmed-meshheading:51828-Immune Adherence Reaction,
pubmed-meshheading:51828-Immunization,
pubmed-meshheading:51828-Immunosuppressive Agents,
pubmed-meshheading:51828-Lectins,
pubmed-meshheading:51828-Mice,
pubmed-meshheading:51828-Sheep,
pubmed-meshheading:51828-T-Lymphocytes
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pubmed:year |
1975
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pubmed:articleTitle |
Inhibition of T- and B-lymphocyte functions by normal immunosuppressive protein.
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pubmed:publicationType |
Journal Article
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