Linked Life Data

518119

Source:http://linkedlifedata.com/resource/pubmed/id/518119

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1980-2-26
pubmed:abstractText
The authors compared the temporal pattern of low-dose oxidant-induced lung injury in rats after exposure to either 1 ppm ozone or 100% oxygen for 24 hr or from treatment with paraquat (20 mg/kg, intraperitoneally). Histological abnormalities in airways, parenchyma, and blood vessels were evaluated from coded and randomized sections and compared with appropriate controls. Drug metabolism by lung endoplasmic reticulum was studied in similarly treated rats as another index of lung injury. Exposure to oxygen caused no discernible morphological or biochemical abnormalities. Exposure to ozone caused histological lesions which appeared early and resolved by 7 to 14 days, whereas paraquat-induced lesions were first evident at about 7 to 14 days. Abnormalities in drug metabolism followed a similar pattern. Low-dose oxidant exposure from ozone and paraquat produce similar histological and biochemical lesions in rat lungs but with distinct temporal patterns.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0003-9896
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
396-401
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Biochemical and morphological correlation of oxidant-induced pulmonary injury: low dose exposure to paraquat, oxygen, and ozone.
pubmed:publicationType
Journal Article