Linked Life Data

513427

Source:http://linkedlifedata.com/resource/pubmed/id/513427

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1980-2-26
pubmed:abstractText
An in vitro cell system has been shown to respond differentially to body fluids from normal subjects and from those with disorders of mucus secretion. The urn cell complex of the marine invertebrate Sipunculus nudus responds to mucus-stimulating substances (MSS) in normal human lacrimal fluids and stool filtrates by producing mucus. The process of mucus secretion can be directly observed, and the amount produced can be measured, in a calibrated light microscope. MSS are decreased in lacrimal fluids of patients with dry-eye conditions, while they are periodically increased in filtered stools of patients with acute Shigella dysentery and acute cholera. MSS are remarkably increased isotonic dilutions of sera of rabbits with acute mucoid enteritis, but are absent from sera of normal rabbits. MSS are present in isotonic dilutions of normal human sera which are heated to 85 degrees C for 4 minutes, but are absent from similarly processed sera of immunosuppressed patients. Mean MSS values of heated sera of children with cystic fibrosis are higher than those of controls. The active factor in tears and serum is a large molecule and is heat-stable.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-7263
pubmed:author
pubmed:issnType
Print
pubmed:volume
145
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-16
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Mucus-stimulating substances in human body fluids assayed in an invertebrate mucous cell system.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.