Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1972-2-25
pubmed:abstractText
A new immunoglobulin A abnormality, absence of assembly of alpha-chain and light-chain, was found in an adult female suffering from recurrent upper respiratory infection and tonsillitis since childhood, but otherwise healthy. The IgA abnormality was manifest in her serum by the presence of free alpha-chains, in her saliva by the presence of alpha-chains bound to secretory piece, and in her urine by the presence of free alpha-chains and free light-chains. The serum IgG and IgM were found to be complete, containing both heavy-chains and light-chains. Evidence for this immunoglobulin A abnormality was also found in the proposita's mother and elder son, demonstrating it to be a hereditary disorder. Studies performed with patient's tonsillar cells in short-term culture, using amino acids-(14)C, revealed synthesis and secretion of both free alpha-chains and free light-chains, in addition to synthesis and secretion of normally assembled IgG and IgM.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-13675766, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-14106294, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-14132658, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-14139537, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-14171555, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-14209281, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-14209282, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-14240539, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-14253478, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-14253483, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-14427849, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4159321, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4159981, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4160439, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4164458, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4164648, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4165344, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4165739, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4168019, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4175121, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4177054, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4177362, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4180120, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4183806, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4184867, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4193528, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4861258, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4956917, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4959869, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-4982231, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-5267137, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-5438427, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-5462703, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-5907290, http://linkedlifedata.com/resource/pubmed/commentcorrection/5129320-6021213
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2726-33
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:5129320-Adult, pubmed-meshheading:5129320-Carbon Isotopes, pubmed-meshheading:5129320-Chromatography, Gel, pubmed-meshheading:5129320-Culture Techniques, pubmed-meshheading:5129320-Electrophoresis, Disc, pubmed-meshheading:5129320-Female, pubmed-meshheading:5129320-Humans, pubmed-meshheading:5129320-Immunoelectrophoresis, pubmed-meshheading:5129320-Immunoglobulin A, pubmed-meshheading:5129320-Immunoglobulin G, pubmed-meshheading:5129320-Immunoglobulin M, pubmed-meshheading:5129320-Immunoglobulins, pubmed-meshheading:5129320-Immunologic Deficiency Syndromes, pubmed-meshheading:5129320-Methods, pubmed-meshheading:5129320-Palatine Tonsil, pubmed-meshheading:5129320-Recurrence, pubmed-meshheading:5129320-Respiratory Tract Infections, pubmed-meshheading:5129320-Saliva, pubmed-meshheading:5129320-Tonsillitis
pubmed:year
1971
pubmed:articleTitle
A hereditary immunoglobulin A abnormality: absence of light-heavy-chain assembly. Study of immunoglobulin synthesis in tonsillar cells.
pubmed:publicationType
Journal Article