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pubmed:otherAbstract |
PIP: Clinical experiences and biological parameters with injections of no rethisterone enanthate (200 mg) given at intervals of 84 days in 10 women aged 20-38 years are reported. Total gonadotropin excretion was decreased in 9 patients and urinary pregnanediol decreased by 50% in all patients. Basal temperature levels remained about .5 degrees C higher for 4-6 weeks after injections. Endometrial biopsies revealed proliferation and secretion phases and slight evidence of an anti-estrogenic effect, but atrophic or hyperplastic changes were not seen. The antiestrogenic effect was also observed in the vaginal epithelium. Other biological parameters were considered normal (plasma cortisol rise after ACTH, oral glucose tolerance, protein-bound iodine, serum cholesterol and total lipids, and liver tests). Side effects included cycle irregularities, spotting, breakthrough bleeding, and weight changes of less than 3 kg. No pregnancies occurred.
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