Linked Life Data

510399

Source:http://linkedlifedata.com/resource/pubmed/id/510399

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1980-2-26
pubmed:abstractText
The effects of clonidine on lumbar sympathetic outflow to the colon and urinary bladder were examined by recording drug-induced changes in spontaneous postganglionic firing and spinal viscero-sympathetic reflexes in the lumbar colonic and hypogastric nerves of the cat. Clonidine in doses between 2--40 micrograms/kg produced a dose dependent depression of spontaneous and evoked discharges in efferents of the hypogastric nerve but did not alter activity in the lumbar colonic nerves. Clonidine also reduced arterial blood pressure and spontaneous firing in the renal nerves. These data coupled with previous observations in this laboratory indicate that spinal sympathetic pathways can exhibit a considerable variation in the sensitivity to the depressant actions of clonidine. This variation in sensitivity may reflect the relative importance of noradrenergic inhibitory mechanisms in the respective pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Effects of clonidine on the lumbar sympathetic pathways to the large intestine and urinary bladder of the cat.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.