|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1971-8-4
|
|
pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Animals, Laboratory,
http://linkedlifedata.com/resource/pubmed/keyword/BLOOD PRESSURE,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Cardiovascular Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Female,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Female--side...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Progestin,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive...,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/EMPHYSEMA,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Medroxyprogesterone...,
http://linkedlifedata.com/resource/pubmed/keyword/Medroxyprogesterone Acetate--side...,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Progestational Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Progesterone--administraction and...,
http://linkedlifedata.com/resource/pubmed/keyword/Progesterone--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0012-3692
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
59
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
659-66
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:otherAbstract |
PIP: Experiments were designed to investigate whether induced emphysema would lead to pulmonary hypertension and cor pulmonale. Also additional proof was sought on the effect of progestational hormones in preventing the occurrence of emphysema in rats. Measurements of mechanical properties of the lung, of pulmonary circulation and cardiac function of the emphysematous rats were made. To some a solution of .5 ml/100 gm body weight of phytohemagglutinin was injected intratrocheally during the first week and 1 mg/100 gm body weight during the second week. Subcutaneous injections were given daily for 6 weeks. 1 group received .1 ml of .5% methocel. Another group received 5 mg/kg progesterone and a third group, .1 mg/kg medroxyprogesterone. Only about 50% of the rats survived all of these procedures. After 6 weeks the special measurements were made. The functional residual capacity of the group receiving phytohemagglutinin was increased to 4.3 ml compared with 3 ml for control rats with saline injections only and 2.8 ml for the rats with tracheal constriciton only. Also histologic examination of the lungs showed a greater percentage of air spaces in rats having had the combined procedure. This histological change was interpreted as pulmonary emphysema. The protective action of progesterone was based on normal values for functional capactiy (3 ml) and normal values for percentage of air spaces in histologic section of the lung. Both the progesterone and medroxyprogesterone prevented the development of the abnormal functional changes of emphysema. Blood changes determined by catheterization of the carotid artery support the occurrence of lesions which were interpreted as emphysema after the tracheal procedures. Tracheal obstruction was considered responsible for the abnormal values of gas tension in the arterial blood. The emphysematous rats showed higher blood pressures than those without emphysema but values for those with only tracheal obstruction were also higher than controls. The high levels of pulmonary arterial pressure were associated with hypoxia and relieved by inhalation of high oxygen. Cardiac output was diminished in those with as well as those without emphysema. This reduction may be an early functional manisfestation prior to cardiac enlargement and cor pulmonale. Rats with tracheal constriction had elevated pulmonary vascular resistance. The only electrocardiographic changes in emphysematous rats were increased height of P waves. Results indicate that the antiemphysematous effect of progesterone is not exerted on the cardiopulmonary system. The reactivity of the bronchial musculature is not affected. The administration of sympathomimetic bronchodilators does not prevent the appearance of emphysema.
|
|
pubmed:meshHeading |
pubmed-meshheading:5087936-Animals,
pubmed-meshheading:5087936-Blood Pressure,
pubmed-meshheading:5087936-Carbon Dioxide,
pubmed-meshheading:5087936-Cardiac Output,
pubmed-meshheading:5087936-Disease Models, Animal,
pubmed-meshheading:5087936-Electrocardiography,
pubmed-meshheading:5087936-Female,
pubmed-meshheading:5087936-Heart,
pubmed-meshheading:5087936-Hypertension, Pulmonary,
pubmed-meshheading:5087936-Lectins,
pubmed-meshheading:5087936-Male,
pubmed-meshheading:5087936-Medroxyprogesterone,
pubmed-meshheading:5087936-Oxygen,
pubmed-meshheading:5087936-Progesterone,
pubmed-meshheading:5087936-Pulmonary Circulation,
pubmed-meshheading:5087936-Pulmonary Emphysema,
pubmed-meshheading:5087936-Pulmonary Heart Disease,
pubmed-meshheading:5087936-Rats,
pubmed-meshheading:5087936-Respiration,
pubmed-meshheading:5087936-Trachea,
pubmed-meshheading:5087936-Vascular Resistance
|
|
pubmed:year |
1971
|
|
pubmed:articleTitle |
Cardiopulmonary effects of progestational agents in emphysematous rats.
|
|
pubmed:publicationType |
Journal Article
|
