Linked Life Data

508663

Source:http://linkedlifedata.com/resource/pubmed/id/508663

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1980-2-28
pubmed:abstractText
The serum cholesterol, triglycerides and electrophoretic lipoprotein patterns of 35 postmenopausal women, who subsequently received sequential mestranol and norethisterone, were compared with those of 35 premenopasual women of the same age and weight. The postmenopausal women had a significantly higher level of serum cholesterol (p less than 0.01) than the premenopausal women, and a significant reduction (p less than 0.001) occurred in this group after two months of therapy. There was no significant difference in level of serum cholesterol between the premenopausal group and the postmenopausal group receiving sequential mestranol and norethisterone for two months. The serum triglycerides were not significantly higher in the postmenopausal group but there was a significant increase (p less than 0.001) after two months of therapy. The marked alteration in lipid levels at the menopause may in part account for the great increase in coronary artery disease in postmenopausal women but whether these changes are reversible by giving hormone therapy remains speculative.
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/Biology, http://linkedlifedata.com/resource/pubmed/keyword/Contraception, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Female, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Progestin, http://linkedlifedata.com/resource/pubmed/keyword/Diseases, http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System, http://linkedlifedata.com/resource/pubmed/keyword/Estrogens, http://linkedlifedata.com/resource/pubmed/keyword/Family Planning, http://linkedlifedata.com/resource/pubmed/keyword/HEART DISEASES, http://linkedlifedata.com/resource/pubmed/keyword/Hematological Effects, http://linkedlifedata.com/resource/pubmed/keyword/Hormones, http://linkedlifedata.com/resource/pubmed/keyword/LIPIDS, http://linkedlifedata.com/resource/pubmed/keyword/Lipid Metabolic Effects, http://linkedlifedata.com/resource/pubmed/keyword/Menopause, http://linkedlifedata.com/resource/pubmed/keyword/Physiology, http://linkedlifedata.com/resource/pubmed/keyword/Reproduction
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0306-5456
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
810-5
pubmed:dateRevised
2004-11-17
pubmed:otherAbstract
PIP: Incidence of cardiovascular disease increases in postmenopausal women and may be related to elevated serum lipid concentrations. The serum cholestrol, triglycerides, and electrophoretic lipoprotein patterns of 35 postmenopausal women receiving sequential mestranol and norethisterone showed a reduction of serum cholesterol with concurrent increase in serum triglycerides after 2 months therapy. Postmenopausal women who were not treated had greater serum cholesterol concentration than either the treated postmenopausal women or 35 premenopausal women matched for age and weight. However, there were no significant concentration differences between the treated postmenopausal women and premenopausal women. It is uncertain whether reduced serum cholesterol levels will reduce the incidence of coronary artery disease nor whether administering estrogens and progestogens will reduce coronary artery disease since there is a marked alteration in lipid metabolism at menopause.
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
The effect of menopausal status and sequential mestranol and norethisterone on serum cholesterol, triglyceride and electrophoretic lipoprotein patterns.
pubmed:publicationType
Journal Article