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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1980-1-24
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pubmed:abstractText |
Topical treatment with 3% phosphonoformate of herpes simplex virus type 1 (HSV)-induced skin infections of hairless mice reduced the severity of skin lesions when the treatment was initiated 3 h after virus inoculation in the lumbosacral area or 3 and 24 h after inoculation in the orofacial area. The mortality was significantly reduced in lumbosacral-infected mice and was completely prevented in orofacial-infected mice when the treatment was initiated with a delay of 24 h after virus inoculation. However, phosphonoformate did not prevent the establishment of latent herpes simplex virus type 1 infections in the spinal and trigeminal ganglia, even when treatment was initiated as early as 3 h after infection.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-1063349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-1181018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-178609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-197008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-199689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-200172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-206200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-208970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-210500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-210669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-213015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-217300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-230784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-301508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-464587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/507784-727763
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
266-70
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:507784-Animals,
pubmed-meshheading:507784-Antiviral Agents,
pubmed-meshheading:507784-Formates,
pubmed-meshheading:507784-Ganglia,
pubmed-meshheading:507784-Herpes Simplex,
pubmed-meshheading:507784-Mice,
pubmed-meshheading:507784-Mice, Nude,
pubmed-meshheading:507784-Nervous System Diseases,
pubmed-meshheading:507784-Organophosphorus Compounds,
pubmed-meshheading:507784-Skin Diseases, Infectious,
pubmed-meshheading:507784-Time Factors
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pubmed:year |
1979
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pubmed:articleTitle |
Latent infections of sensory ganglia as influenced by phosphonoformate treatment of herpes simplex virus-induced skin infections in hairless mice.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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