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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0003255,
umls-concept:C0003320,
umls-concept:C0007634,
umls-concept:C0021055,
umls-concept:C0178539,
umls-concept:C0441889,
umls-concept:C0597357,
umls-concept:C0871161,
umls-concept:C1167622,
umls-concept:C1327616,
umls-concept:C1707520,
umls-concept:C2603343
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pubmed:issue |
2
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pubmed:dateCreated |
1972-5-1
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pubmed:abstractText |
Heterogeneity with regard to affinity of anti-hapten antibody was demonstrated at the cellular level in mice. The heterogeneity was shown at the level of single antibody-forming cells using hapten inhibition of hemolytic antibody plaque formation as a measure of affinity. The affinity increased with time after immunization. A high antigen dose initially resulted in relatively low affinity antibody production as compared to the affinity of the antibody production in animals immunized with a low dose. Affinity specialization of immunological memory cells was demonstrated, since it was possible to specifically fractionate such cells with regard to affinity on hapten-protein-coated plastic bead columns. High affinity memory cells showed a higher tendency to become retained in the columns than did low affinity memory cells. The data in a direct way demonstrate that memory cells carrying membrane-associated receptors of a certain affinity for the antigen are determined to release antibody of a similar affinity after stimulation with antigen.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-14076917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-14214095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-4101344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-4101973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-4169440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-4181830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-4864671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-4911386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-4927594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-5105301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-5349738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-5528414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-5635623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-5782770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5060293-5939478
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
135
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
312-22
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pubmed:dateRevised |
2010-6-22
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pubmed:meshHeading |
pubmed-meshheading:5060293-Animals,
pubmed-meshheading:5060293-Antibodies,
pubmed-meshheading:5060293-Antibody Formation,
pubmed-meshheading:5060293-Antigen-Antibody Complex,
pubmed-meshheading:5060293-Antigens,
pubmed-meshheading:5060293-Binding Sites,
pubmed-meshheading:5060293-Cell Membrane,
pubmed-meshheading:5060293-Guinea Pigs,
pubmed-meshheading:5060293-Haptens,
pubmed-meshheading:5060293-Immunity, Cellular,
pubmed-meshheading:5060293-Immunologic Memory,
pubmed-meshheading:5060293-Lymphoid Tissue,
pubmed-meshheading:5060293-Mice,
pubmed-meshheading:5060293-Mice, Inbred Strains,
pubmed-meshheading:5060293-Time Factors
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pubmed:year |
1972
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pubmed:articleTitle |
Studies on antibody affinity at the cellular level. Correlation between binding properties of secreted antibody and cellular receptor for antigen on immunological memory cells.
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pubmed:publicationType |
Journal Article
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