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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1975-11-6
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pubmed:abstractText |
Human T lymphocytes from patients with ragweed hay fever, when exposed to ragweed antigen E (AgE) in vitro, produced an activity that, in the presence of antigen, induced B cells from AgE-sensitive donors to synthesize and secrete IgE and IgG antibodies to AgE. Anti-AgE specificity was assessed both in vitro and in vivo. B lymphocytes from ragweed-sensitive individuals exposed in vitro to AgE alone failed to transform or to secrete antibody to AgE. The T cells activity had no effect on B cells of individuals not sensitive to AgE. The results of this study suggest that the human reaginic antibody response requires T and B cell cooperation. The experimental approach used may be a useful model for the investigation of the antibody responses of allergic individuals.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/50327-4130213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/50327-4200776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/50327-4324259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/50327-4578158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/50327-4605055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/50327-47796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/50327-4856400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/50327-4945477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/50327-4962018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/50327-4986654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/50327-5035246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/50327-5123223
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
386-90
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:50327-Adult,
pubmed-meshheading:50327-Allergens,
pubmed-meshheading:50327-Antigen-Antibody Reactions,
pubmed-meshheading:50327-B-Lymphocytes,
pubmed-meshheading:50327-Child,
pubmed-meshheading:50327-DNA,
pubmed-meshheading:50327-Epitopes,
pubmed-meshheading:50327-Humans,
pubmed-meshheading:50327-Immune Sera,
pubmed-meshheading:50327-Immunoglobulin E,
pubmed-meshheading:50327-Immunoglobulin G,
pubmed-meshheading:50327-Microscopy, Electron,
pubmed-meshheading:50327-Models, Biological,
pubmed-meshheading:50327-Pollen,
pubmed-meshheading:50327-Skin Tests,
pubmed-meshheading:50327-T-Lymphocytes
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pubmed:year |
1975
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pubmed:articleTitle |
Cooperation between human thymus-derived and bone marrow-derived lymphocytes in the antibody response to ragweed antigen E in vitro.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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