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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1972-7-12
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pubmed:abstractText |
Inosinic acid dehydrogenase was evaluated in normal subjects and in patients with the Lesch-Nyhan syndrome. A significant difference in activity was found between erythrocytes derived from normal controls (1.21+/-0.47 pmoles/hr per mg protein) and from 15 patients with the Lesch-Nyhan syndrome (6.72+/-6.23 pmoles/hr per mg protein). However, no difference in activity was demonstrable in muscle or leukocytes derived from normal and Lesch-Nyhan patients. The increased activity of inosinic acid dehydrogenase in erythrocytes from patients with the Lesch-Nyhan syndrome is due to stabilization of the enzyme in vivo as well as the absence of an inhibitor which is present in erythrocytes from normal subjects.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-13428767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-13906488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-14142409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-14233155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-14297493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-14329695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-14476749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-4301223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-4313815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-4324023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-5274461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-5350202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-5410854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-5444709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-5635013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-5650894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/5024037-6020292
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1398-404
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:5024037-Analysis of Variance,
pubmed-meshheading:5024037-Athetosis,
pubmed-meshheading:5024037-Carbon Isotopes,
pubmed-meshheading:5024037-Erythrocytes,
pubmed-meshheading:5024037-Guanine Nucleotides,
pubmed-meshheading:5024037-Humans,
pubmed-meshheading:5024037-Inosine Nucleotides,
pubmed-meshheading:5024037-Intellectual Disability,
pubmed-meshheading:5024037-Lesch-Nyhan Syndrome,
pubmed-meshheading:5024037-Nucleotides,
pubmed-meshheading:5024037-Oxidoreductases,
pubmed-meshheading:5024037-Purine-Pyrimidine Metabolism, Inborn Errors,
pubmed-meshheading:5024037-Self Mutilation,
pubmed-meshheading:5024037-Transferases
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pubmed:year |
1972
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pubmed:articleTitle |
Inosinic acid dehydrogenase activity in the Lesch-Nyhan syndrome.
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pubmed:publicationType |
Journal Article
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