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rdf:type |
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lifeskim:mentions |
umls-concept:C0015744,
umls-concept:C0018066,
umls-concept:C0022735,
umls-concept:C0030685,
umls-concept:C0036884,
umls-concept:C0041408,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1963578,
umls-concept:C2911691
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pubmed:issue |
2
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|
pubmed:dateCreated |
1975-10-28
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|
pubmed:abstractText |
The present study was designed to elucidate the feedback relationship between the release of pituitary gonadotropins and sex steroid hormones in Turner's syndrome and Klinefelter's syndrome. LH-RH stimulation test was employed to evaluate the effects of sex steroids on the release of gonadotropins. The release of gonadotropins in response to LH-RH as well as in baseline level was suppressed after the treatment with estrogen (mestranol 0.08 mg/day) for 10 days, followed by the treatment of the same period with estrogen (mestranol 0.08 mg/day) and progesterone (chlormadinone acetate 2.0 mg/day) in combination in both syndromes. The inhibitory effect of the combined treatment was greater than that of the treatment with estrogen alone. Administration of testosterone propionate (25 mg/day) for 3 days resulted in suppression of the release of both gonadotropins in baseline level and in response to LH-RH in both syndromes, but the suppressive effect appeared to be less complete as compared with that of estrogen or estrogen-progesterone. It was thus verified that the feedback interaction between the pituitary gonadotropin release and sex steroids such as estrogen, estrogen-progesterone or testosterone was operative in the same fashion in the patients with Turner's syndrome and Klinefelter's syndrome.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0013-7219
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
111-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:50229-Adolescent,
pubmed-meshheading:50229-Adult,
pubmed-meshheading:50229-Chlormadinone Acetate,
pubmed-meshheading:50229-Feedback,
pubmed-meshheading:50229-Female,
pubmed-meshheading:50229-Follicle Stimulating Hormone,
pubmed-meshheading:50229-Gonadal Steroid Hormones,
pubmed-meshheading:50229-Gonadotropin-Releasing Hormone,
pubmed-meshheading:50229-Gonadotropins, Pituitary,
pubmed-meshheading:50229-Humans,
pubmed-meshheading:50229-Klinefelter Syndrome,
pubmed-meshheading:50229-Luteinizing Hormone,
pubmed-meshheading:50229-Male,
pubmed-meshheading:50229-Mestranol,
pubmed-meshheading:50229-Radioimmunoassay,
pubmed-meshheading:50229-Steroids,
pubmed-meshheading:50229-Testosterone,
pubmed-meshheading:50229-Turner Syndrome
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pubmed:year |
1975
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pubmed:articleTitle |
The feedback effects of sex steroid hormones on pituitary gonadotropin release in Turner's syndrome and Klinefelter's syndrome.
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pubmed:publicationType |
Journal Article
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