| pubmed-article:5022172 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:5022172 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:5022172 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:5022172 | lifeskim:mentions | umls-concept:C1621374 | lld:lifeskim |
| pubmed-article:5022172 | lifeskim:mentions | umls-concept:C1304890 | lld:lifeskim |
| pubmed-article:5022172 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:5022172 | lifeskim:mentions | umls-concept:C0015023 | lld:lifeskim |
| pubmed-article:5022172 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:5022172 | pubmed:dateCreated | 1972-7-3 | lld:pubmed |
| pubmed-article:5022172 | pubmed:abstractText | In a defined medium with added ethionine plus low methionine, phenylalanine, tryptophan, tyrosine, adenine, and additional methionine reversed inhibition of the enteric yeast Candida slooffii by ethionine. Isoleucine and 7-methylguanine restored half-maximal growth. Choline but not triethylcholine inhibited C. slooffii. 6-Mercaptopurine reversed ethionine inhibition and also synergistic inhibition by ethionine plus choline. Protection against ethionine by adenine plus aromatics was also evident with log-phase cells in the absence of methionine. Incorporation of ethionine-ethyl-1-(14)C by resting cells was partially inhibited by aromatic amino acids and methionine. Ethionine depressed incorporation of (3)H-phenylalanine but not of (3)H-adenine. Ethionine-resistant mutants were isolated which incorporated ethionine efficiently and degraded it to yet unidentified substances not including 5'-ethylthioadenosine. Ethionine-sensitive cells accumulated more S-adenosylethionine (SAE) than resistant mutants. Adenine was a good precursor of SAE. Radioactivity from ethionine-ethyl-1-(14)C was recovered from cell fractions of ethionine-sensitive cells with the following distribution: cold trichloroacetic acid-soluble > hot trichloroacetic acid-insoluble > lipids > deoxyribonucleic acid > ribonucleic acid. Total radioactivity recovered from ethionine-sensitive cells was twice as much as that from ethionine-resistant mutants. | lld:pubmed |
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| pubmed-article:5022172 | pubmed:language | eng | lld:pubmed |
| pubmed-article:5022172 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:5022172 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:5022172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:5022172 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:5022172 | pubmed:month | May | lld:pubmed |
| pubmed-article:5022172 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:5022172 | pubmed:author | pubmed-author:TravassosL... | lld:pubmed |
| pubmed-article:5022172 | pubmed:author | pubmed-author:MendonçaL CLC | lld:pubmed |
| pubmed-article:5022172 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:5022172 | pubmed:volume | 110 | lld:pubmed |
| pubmed-article:5022172 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:5022172 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:5022172 | pubmed:pagination | 643-51 | lld:pubmed |
| pubmed-article:5022172 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:5022172 | pubmed:year | 1972 | lld:pubmed |
| pubmed-article:5022172 | pubmed:articleTitle | Metabolism of ethionine in ethionine-sensitive and ethionine-resistant cells of the enteric yeast Candida slooffii. | lld:pubmed |
| pubmed-article:5022172 | pubmed:publicationType | Journal Article | lld:pubmed |
