Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1975-11-8
|
| pubmed:abstractText |
An in vitro cell line (SGT) derived from a mouse submaxillary gland adenocarcinoma (TGS) containing A and B viral particles maintained its oncogenicity only for newborn isogeneic hosts (C3H/He mice) immunosuppressed with antithymocyte serum. Inoculation into adult isogeneic animals did not cause tumor but provided partial protection against a challenge with TGS cells. The loss of oncogenicity for nonimmunosuppressed isogeneic hosts was accompanied by the acqusition of oncogenicity for adult, nonimmunosuppressed, xenogeneic hosts (golden hamsters) given subcutaneous inoculations of SGT cells on the back. From the tumor grown in the hamster, which is histologically similar to the original tumor of the mouse, an in vitro cell line (HWS) was derived. The comparative analysis of the 2 cell lines, SGT and HWS, led to the following conclusions: (a) the karyological pattern of the 2 cell lines in virtually the same; (b) the cell surface antigenic pattern is similar for the 2 cell lines, as determined by colony inhibition test and cytotoxicty test; (c) the cells of the HWS line behave serologically as a mouse-hamster hybrid, also as determined by colony inhibition and cytotoxicity tests; (d) both cell lines have only intracytoplasmic viral particles of the A type; and (e) agglutination with the plant lectins concanavalin A and wheat germ agglutinin occurs at lower concentrations of agglutinin for HWS cells than for SGT cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0008-5472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2394-402
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:50130-Adenocarcinoma,
pubmed-meshheading:50130-Agglutination,
pubmed-meshheading:50130-Animals,
pubmed-meshheading:50130-Animals, Newborn,
pubmed-meshheading:50130-Antigens, Neoplasm,
pubmed-meshheading:50130-Cell Division,
pubmed-meshheading:50130-Cell Line,
pubmed-meshheading:50130-Clone Cells,
pubmed-meshheading:50130-Cricetinae,
pubmed-meshheading:50130-Cytoplasm,
pubmed-meshheading:50130-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:50130-Epitopes,
pubmed-meshheading:50130-Female,
pubmed-meshheading:50130-Immunologic Techniques,
pubmed-meshheading:50130-Karyotyping,
pubmed-meshheading:50130-Lectins,
pubmed-meshheading:50130-Male,
pubmed-meshheading:50130-Mice,
pubmed-meshheading:50130-Mice, Inbred C3H,
pubmed-meshheading:50130-Neoplasm Transplantation,
pubmed-meshheading:50130-Neoplasms, Experimental,
pubmed-meshheading:50130-Oncogenic Viruses,
pubmed-meshheading:50130-Salivary Gland Neoplasms,
pubmed-meshheading:50130-Submandibular Gland,
pubmed-meshheading:50130-Transplantation, Heterologous,
pubmed-meshheading:50130-Transplantation, Homologous
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
Viral expression, oncogenicity, and antigenicity of a mouse salivary gland tumor and two cell lines derived from it.
|
| pubmed:publicationType |
Journal Article
|