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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1980-1-24
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pubmed:abstractText |
The role of central nervous system (CNS) catecholamines in the development of hypertension and the control of drinking behavior was assessed in rats by depleting these amines with 6-hydroxydopamine (6-OHDA). Intraventricular administration of 6-OHDA completely prevented the development of one-kidney renal hypertension and abolished the associated increase in water consumption. 6-OHDA-treated rats showed deficits in drinking behavior when challenged with subcutaneous injections of angiotensin II (AII) and hypertonic sodium chloride. The acute pressor responses produced by intraventricular injections of AII and carbachol were virtually abolished by central catecholamine depletion. However, drinking produced by central cholinergic stimulation remained intact while AII drinking was significantly reduced. These data demonstrate that the integrity of CNS catecholamines is required for the development of one-kidney renal hypertension and the increased drinking which accompanies it. In addition, destruction of central catecholamine-containing neurons allows for a specific dissociation of the pressor and drinking responses produced by central cholinergic but not AII stimulation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
178
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
161-73
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:497858-Animals,
pubmed-meshheading:497858-Blood Pressure,
pubmed-meshheading:497858-Catecholamines,
pubmed-meshheading:497858-Drinking Behavior,
pubmed-meshheading:497858-Hydroxydopamines,
pubmed-meshheading:497858-Hypertension, Renal,
pubmed-meshheading:497858-Male,
pubmed-meshheading:497858-Rats,
pubmed-meshheading:497858-Thirst
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pubmed:year |
1979
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pubmed:articleTitle |
Role of central catecholamines in the control of blood pressure and drinking behavior.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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