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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1980-1-28
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pubmed:abstractText |
1 The effect of 5-hydroxytryptamine on contractile responses to sympathetic nerve stimulation has been studied in the dog isolated saphenous vein.2 Electrical stimulation (0.1 to 10 Hz) of dog saphenous vein strips produced frequency-dependent contractions. Contractions produced by stimulation at 2 Hz were almost completely blocked by tetrodotoxin (3.1 x 10(-8) mol/l) or phentolamine (5.0 x 10(-6) mol/l) but mecamylamine (5.0 x 10(-6) mol/l) had little effect. This suggests that the contractions were mediated predominantly through noradrenaline release from postganglionic noradrenergic nerves.3 Contractions produced by intermittent electrical stimulation at 2 Hz were inhibited by 5-hydroxy-tryptamine (1.0 x 10(-9) to 1.0 x 10(-7) mol/l) in a concentration-dependent manner whilst contractions induced by exogenous noradrenaline were not affected.4 The inhibitory action of 5-hydroxytryptamine was most marked at low frequencies of stimulation and with low pulse numbers.5 High external calcium concentrations (3.9 and 5.2 x 10(-3) mol/l) reduced the inhibitory action of 5-hydroxytryptamine.6 Cyproheptadine (1.0 x 10(-8) mol/l to 1.0 x 10(-6) mol/l) or morphine (1.0 x 10(-7) mol/l to 1.0 x 10(-5) mol/l) did not antagonize the inhibitory action of 5-hydroxytryptamine. Methysergide (1.0 x 10(-7) mol/l) slightly reduced the contractions produced by electrical stimulation and only weakly antagonized the action of 5-hydroxytryptamine.7 It is suggested that a 5-hydroxytryptamine receptor exists presynaptically in the dog isolated saphenous vein strip and that stimulation of this receptor by low concentrations of 5-hydroxytryptamine inhibits the release of noradrenaline from noradrenergic nerves. This receptor type is resistant to blockade by ;classical' 5-hydroxytryptamine antagonists.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-1126367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-1248510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-1261590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-13460238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-13761710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-14025623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-180448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-18248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-183912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-184872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-186274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-191214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-198824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-20240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-326580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-4150044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-4212942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-4347257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-4435025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-4685970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-4697156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-5026399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-5728319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-667430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/497528-926021
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
247-54
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:497528-Animals,
pubmed-meshheading:497528-Calcium,
pubmed-meshheading:497528-Dogs,
pubmed-meshheading:497528-Electric Stimulation,
pubmed-meshheading:497528-Muscle, Smooth, Vascular,
pubmed-meshheading:497528-Muscle Contraction,
pubmed-meshheading:497528-Norepinephrine,
pubmed-meshheading:497528-Saphenous Vein,
pubmed-meshheading:497528-Serotonin,
pubmed-meshheading:497528-Serotonin Antagonists,
pubmed-meshheading:497528-Synapses
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pubmed:year |
1979
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pubmed:articleTitle |
Presynaptic inhibitory action of 5-hydroxytryptamine in dog isolated saphenous vein.
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pubmed:publicationType |
Journal Article,
In Vitro
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