| pubmed-article:4963458 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4963458 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:4963458 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:4963458 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:4963458 | lifeskim:mentions | umls-concept:C0230779 | lld:lifeskim |
| pubmed-article:4963458 | lifeskim:mentions | umls-concept:C0178602 | lld:lifeskim |
| pubmed-article:4963458 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:4963458 | lifeskim:mentions | umls-concept:C0012411 | lld:lifeskim |
| pubmed-article:4963458 | lifeskim:mentions | umls-concept:C0442120 | lld:lifeskim |
| pubmed-article:4963458 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:4963458 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:4963458 | pubmed:dateCreated | 1967-12-14 | lld:pubmed |
| pubmed-article:4963458 | pubmed:abstractText | 1. Changes in the structure and function of the rough-surfaced endoplasmic reticulum of the rat liver as deduced by electron microscopy, polysome analysis and the amino acid-incorporating activity of microsome fractions have been followed at various time-intervals after a single intraperitoneal dose of the hepatocarcinogen 4-dimethylaminoazobenzene. 2. The earliest effect observed was detachment of polysomes and disorganization and vesiculation of the cisternae of the rough-surfaced endoplasmic reticulum. This occurred after 6hr. 3. Subsequent to this was a phase of polysome disaggregation accompanied by impaired amino acid-incorporating activity by microsomes together with a much enhanced stimulating effect of polyuridylic acid on amino acid uptake. This reached a maximum at 24hr. 4. By 40hr. polysomes had re-formed and the amino acid-incorporating activity, together with the polyuridylic acid effect, were similar to those in controls. 5. It was not until 112hr. that something like the normal structure of the rough-surfaced endoplasmic reticulum was re-established. 6. It is not yet possible to relate these changes specifically with the process of azo-dye carcinogenesis. | lld:pubmed |
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| pubmed-article:4963458 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:4963458 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4963458 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4963458 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:4963458 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:4963458 | pubmed:author | pubmed-author:KettererBB | lld:pubmed |
| pubmed-article:4963458 | pubmed:author | pubmed-author:HoltS JSJ | lld:pubmed |
| pubmed-article:4963458 | pubmed:author | pubmed-author:Ross-MansellP... | lld:pubmed |
| pubmed-article:4963458 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4963458 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:4963458 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4963458 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4963458 | pubmed:pagination | 692-8 | lld:pubmed |
| pubmed-article:4963458 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4963458 | pubmed:year | 1967 | lld:pubmed |
| pubmed-article:4963458 | pubmed:articleTitle | The effect of a single intraperitoneal dose of the hepatocarcinogen 4-dimethylaminoazobenzene on the rough-surfaced endoplasmic reticulum of the liver of the rat. | lld:pubmed |
| pubmed-article:4963458 | pubmed:publicationType | Journal Article | lld:pubmed |
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