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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1967-12-14
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pubmed:abstractText |
1. Changes in the structure and function of the rough-surfaced endoplasmic reticulum of the rat liver as deduced by electron microscopy, polysome analysis and the amino acid-incorporating activity of microsome fractions have been followed at various time-intervals after a single intraperitoneal dose of the hepatocarcinogen 4-dimethylaminoazobenzene. 2. The earliest effect observed was detachment of polysomes and disorganization and vesiculation of the cisternae of the rough-surfaced endoplasmic reticulum. This occurred after 6hr. 3. Subsequent to this was a phase of polysome disaggregation accompanied by impaired amino acid-incorporating activity by microsomes together with a much enhanced stimulating effect of polyuridylic acid on amino acid uptake. This reached a maximum at 24hr. 4. By 40hr. polysomes had re-formed and the amino acid-incorporating activity, together with the polyuridylic acid effect, were similar to those in controls. 5. It was not until 112hr. that something like the normal structure of the rough-surfaced endoplasmic reticulum was re-established. 6. It is not yet possible to relate these changes specifically with the process of azo-dye carcinogenesis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-13607415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-13740412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-13764136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-13975866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-13986422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-14000153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-14062648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-14079162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-14195607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-14207459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-14240664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-14242873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-14323569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-14324825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-14337508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-14434277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-16749021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-4954064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-4956888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-5911517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4963458-5915976
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
692-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4963458-Animals,
pubmed-meshheading:4963458-Carbon Isotopes,
pubmed-meshheading:4963458-Carcinogens,
pubmed-meshheading:4963458-Endoplasmic Reticulum,
pubmed-meshheading:4963458-Liver,
pubmed-meshheading:4963458-Male,
pubmed-meshheading:4963458-Microscopy, Electron,
pubmed-meshheading:4963458-Microsomes,
pubmed-meshheading:4963458-Neoplasms, Experimental,
pubmed-meshheading:4963458-Phenylalanine,
pubmed-meshheading:4963458-Polynucleotides,
pubmed-meshheading:4963458-RNA, Messenger,
pubmed-meshheading:4963458-Rats,
pubmed-meshheading:4963458-Ribosomes,
pubmed-meshheading:4963458-Uracil Nucleotides,
pubmed-meshheading:4963458-p-Dimethylaminoazobenzene
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pubmed:year |
1967
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pubmed:articleTitle |
The effect of a single intraperitoneal dose of the hepatocarcinogen 4-dimethylaminoazobenzene on the rough-surfaced endoplasmic reticulum of the liver of the rat.
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pubmed:publicationType |
Journal Article
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