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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1970-11-25
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Abortifacient Agents,
http://linkedlifedata.com/resource/pubmed/keyword/Abortion, Drug Induced,
http://linkedlifedata.com/resource/pubmed/keyword/Abortion, Induced,
http://linkedlifedata.com/resource/pubmed/keyword/Adenosine Cyclic Monophosphate,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Fertility Control, Postconception,
http://linkedlifedata.com/resource/pubmed/keyword/Infertility,
http://linkedlifedata.com/resource/pubmed/keyword/Menstruation,
http://linkedlifedata.com/resource/pubmed/keyword/Myometrial Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Prostaglandins--therapeutic use,
http://linkedlifedata.com/resource/pubmed/keyword/Reproduction
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0030-1124
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
66
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1008-12
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:otherAbstract |
PIP: Research on the physiopathologic and biochemical nature of prostaglandins (PGs) suggest that PGs play a role in reproductive physiology. In vitro studies show that the PGE series decrease the motility of the human uterus, fallopian tubes, and ureter, and produce vasodilatation. PGFs cause vasoconstriction and increased motility of the uterus, fallopian tubes, ureter, and gastrointestinal muscle. PGs are also known to inhibit lipolysis, platelet aggregation, and gastric secretion. The exact mechanism of PGs are not fully understood, but evidence suggests that many responses can be attributed to interference with the enzyme adenyl cyclase, which catalyzes the formation of adenosine 3',5'-monophosphate (cyclic AMP) from adenosine triphosphate. The adenyl cyclase-cyclic AMP system mediates lipolysis, steroidogenesis, gastric secretion, certain smooth muscle motility responses, and increase in permeability due to vasopressin. Early studies of the myometrial effects of PGs showed that the PGE series inhibited the motility of the human myometrium in vitro while the PGF series produced mixed responses. The role of PGF2alpha in parturition has not been established but evidence suggests that it has a potential role as an oxytocic in cases of therapeutic abortion. In the area of human fertility, the physiologic role of PGs in seminal fluid is hypothesized to facilitate the migration of spermatozoa from the vagina into the uterine cavity. Karolinska Institute researchers have found that some infertile males have low PG levels in their ejaculates and are now working with methods of improving the PG levels to improve their fertility. Pickles et al. proposed a potential role for PGs in the etiology of dysmenorrhea, having found a significantly higher ratio of PGF to PGE in a series of patients with severe dysmenorrhea than in a comparable series of normal patients. The luteolytic and antinidatory effects of PGF2alpha are being investigated and studies appear encouraging. PGs have therapeutic potentials in induction of labor, treatment of infertility, morning-after conception, treatment of dysmenorrhea, and contraception by alteration of fallopian tube motility.
|
| pubmed:meshHeading |
pubmed-meshheading:4918753-Animals,
pubmed-meshheading:4918753-Arachidonic Acids,
pubmed-meshheading:4918753-Cats,
pubmed-meshheading:4918753-Cattle,
pubmed-meshheading:4918753-Contraceptive Agents,
pubmed-meshheading:4918753-Corpus Luteum,
pubmed-meshheading:4918753-Dogs,
pubmed-meshheading:4918753-Fallopian Tubes,
pubmed-meshheading:4918753-Fatty Acids,
pubmed-meshheading:4918753-Female,
pubmed-meshheading:4918753-Goats,
pubmed-meshheading:4918753-Horses,
pubmed-meshheading:4918753-Humans,
pubmed-meshheading:4918753-Infertility, Female,
pubmed-meshheading:4918753-Labor, Obstetric,
pubmed-meshheading:4918753-Male,
pubmed-meshheading:4918753-Menstruation,
pubmed-meshheading:4918753-Movement,
pubmed-meshheading:4918753-Pregnancy,
pubmed-meshheading:4918753-Prostaglandins,
pubmed-meshheading:4918753-Rabbits,
pubmed-meshheading:4918753-Reproduction,
pubmed-meshheading:4918753-Semen,
pubmed-meshheading:4918753-Sheep,
pubmed-meshheading:4918753-Uterus
|
| pubmed:year |
1970
|
| pubmed:articleTitle |
The role of prostaglandins in reproductive physiology.
|
| pubmed:publicationType |
Journal Article,
Review
|