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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1979-12-18
|
| pubmed:abstractText |
A series of phenyl-substituted derivatives of 1,2-dimethyl-3,4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate) (1) were synthesized and tested for antileukemic activity against P388 lymphocytic leukemia in the mouse. All of the compounds tested, 1a--r, showed significant activity in this assay. Selected derivatives of 1 were tested against several bacteria and were found to have little or no antibacterial activity in the systems examined.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
977-80
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:490542-Animals,
pubmed-meshheading:490542-Antineoplastic Agents,
pubmed-meshheading:490542-Bacteria,
pubmed-meshheading:490542-Carbamates,
pubmed-meshheading:490542-Chemical Phenomena,
pubmed-meshheading:490542-Chemistry,
pubmed-meshheading:490542-Leukemia P388,
pubmed-meshheading:490542-Mice,
pubmed-meshheading:490542-Pyrroles
|
| pubmed:year |
1979
|
| pubmed:articleTitle |
Antileukemic activity of derivatives of 1,2-dimethyl-3,4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate).
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|