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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
1979-12-18
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pubmed:abstractText |
Black tuberculosis patients from South Africa (S. A.) as well as from Birmingham, Alabama, U.S.A., showed a higher percentage of fast inactivators of isoniazid (INH) than that found in the North American white population, simultaneously sampled. In S. A. blacks, the frequency of fast inactivation was 57.9--59.6%, while in American blacks of Birmingham it amounted to 60.3%; in comparison to the above groups the rate of fast acetylators in Canadian Caucasians was 41.9% and in the USA white population 41.0%. For phenotyping of isoniazid inactivators a urine test was used. In this method the concentrations of INH (including isoniazidhydrazones) as well as acetylisoniazid were determined in the specimens collected 6--8 hrs following a test dose of 10 mg/kg INH.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0340-0026
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
311-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:489198-Administration, Oral,
pubmed-meshheading:489198-Adolescent,
pubmed-meshheading:489198-Adult,
pubmed-meshheading:489198-African Continental Ancestry Group,
pubmed-meshheading:489198-Aged,
pubmed-meshheading:489198-Canada,
pubmed-meshheading:489198-European Continental Ancestry Group,
pubmed-meshheading:489198-Female,
pubmed-meshheading:489198-Humans,
pubmed-meshheading:489198-Injections, Intramuscular,
pubmed-meshheading:489198-Isoniazid,
pubmed-meshheading:489198-Male,
pubmed-meshheading:489198-Middle Aged,
pubmed-meshheading:489198-Phenotype,
pubmed-meshheading:489198-South Africa,
pubmed-meshheading:489198-United States
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pubmed:year |
1979
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pubmed:articleTitle |
Comparison of isoniazid phenotyping of black and white patients with emphasis on South African blacks.
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pubmed:publicationType |
Journal Article,
Comparative Study
|