Linked Life Data

4879882

Source:http://linkedlifedata.com/resource/pubmed/id/4879882

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1968-12-20
pubmed:abstractText
1. Caerulein, as expected from its amino-acid composition and sequence, has a potent stimulant action on gastric secretion in the dog, the rat and the frog.2. In the denervated fundic pouch of the dog, caerulein increases the rate of flow of gastric juice and the outputs of acid and pepsin. Acid concentration and pepsin concentration in caerulein-produced juice are generally greater than in control juice. The threshold subcutaneous dose of caerulein is 0.15-0.5 mug/kg and the threshold rate of intravenous infusion 0.25-0.5 mug/kg per hr. Rapid intravenous injection is ineffective. On a molar basis, caerulein is approximately twice as active as human gastrin I on volume and acid output of the gastric pouch and 4 times as active on pepsin output.3. Sustained acid secretion of the fundic pouch produced by histamine infusion is inhibited by caerulein, administered either intravenously or subcutaneously. In turn, acid secretion elicited by caerulein is inhibited by atropine.4. In the rat, the activity ratio of caerulein to human gastrin I is 7-30, calculated on a molar basis, and is thus considerably greater than in the dog. Further, caerulein is 3 times more active than cholecystokinin-pancreozymin. Tested on the perfused stomach preparation of the rat, the threshold dose of caerulein by rapid intravenous injection is 25 ng/kg, by intravenous infusion 0.25 mug/kg per hr, and by subcutaneous injection 0.25 to 0.5 mug/kg.5. The activity of caerulein is sharply reduced by pretreatment of the rats with the histamine liberator 48/80 and potentiated by pretreatment with the diamine oxidase inhibitor aminoguanidine. When caerulein is given by rapid intravenous injection during a priming infusion of histamine its effect is enhanced and considerably prolonged.6. The isolated mucosa of the frog stomach is extremely sensitive to caerulein which, in a concentration of a few pg/ml., stimulates active transport of chloride.7. Qualitative and quantitative differences in the action of gastrin and caerulein are pointed out, and particular emphasis is laid on the importance of esterification of the tyrosyl residue for the biological activity of caerulein.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4879882-13599113, http://linkedlifedata.com/resource/pubmed/commentcorrection/4879882-14159395, http://linkedlifedata.com/resource/pubmed/commentcorrection/4879882-14256808, http://linkedlifedata.com/resource/pubmed/commentcorrection/4879882-16748230, http://linkedlifedata.com/resource/pubmed/commentcorrection/4879882-4380160, http://linkedlifedata.com/resource/pubmed/commentcorrection/4879882-4859802, http://linkedlifedata.com/resource/pubmed/commentcorrection/4879882-5335881, http://linkedlifedata.com/resource/pubmed/commentcorrection/4879882-5337293, http://linkedlifedata.com/resource/pubmed/commentcorrection/4879882-5649531, http://linkedlifedata.com/resource/pubmed/commentcorrection/4879882-5660166, http://linkedlifedata.com/resource/pubmed/commentcorrection/4879882-5687588, http://linkedlifedata.com/resource/pubmed/commentcorrection/4879882-5693208, http://linkedlifedata.com/resource/pubmed/commentcorrection/4879882-6033738, http://linkedlifedata.com/resource/pubmed/commentcorrection/4879882-6049094
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
311-29
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1968
pubmed:articleTitle
The actions of caerulein on gastric secretion of the dog and the rat.
pubmed:publicationType
Journal Article