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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1979-12-27
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pubmed:abstractText |
The mechanism by which prolactin, a peptide hormone, regulates casein gene expression has been studied in mammary gland organ culture. After prolactin addition, a 2-4 fold increase in the rate of casein mRNA transcription was observed within 1 hr and maintained for at least 24 hr. This increased rate of transcription is not sufficient to account for the mass accumulation of casein mRNA. The half-life of casein mRNA is also increased 17-25 fold in the presence of prolactin. This change in casein mRNA half-life, coupled with a 2-4 fold increase in the rate of transcription, can account for the normal accumulation of casein mRNA observed after prolactin addition. This hormone-induced change in casein mRNA half-life appeared to be selective, since prolactin was found to exert only a slight effect (1-4 fold) on the half-life of poly(A) RNA determined under identical pulse-chase conditions. The hormonal regulation of casein gene expression thus does not app-ar to be an "all or none" process occurring only at the transcriptional or post-transcriptional levels, but rather may involve a coordinated response at several levels to permit the efficient expression of specialized differentiated functions.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0092-8674
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1013-23
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:487427-Animals,
pubmed-meshheading:487427-Caseins,
pubmed-meshheading:487427-Female,
pubmed-meshheading:487427-Genes,
pubmed-meshheading:487427-Mammary Glands, Animal,
pubmed-meshheading:487427-Organ Culture Techniques,
pubmed-meshheading:487427-Pregnancy,
pubmed-meshheading:487427-Prolactin,
pubmed-meshheading:487427-RNA, Messenger,
pubmed-meshheading:487427-Rats,
pubmed-meshheading:487427-Time Factors,
pubmed-meshheading:487427-Transcription, Genetic
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pubmed:year |
1979
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pubmed:articleTitle |
Prolactin-mediated transcriptional and post-transcriptional control of casein gene expression.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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