Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1974-10-4
pubmed:abstractText
Since the concept of an elevated venous tone in congestive heart failure (CHF) has been recently questioned, the venous volume of the elevated calf at a venous pressure of 30 mm Hg (VV[30]) was determined in 18 normal volunteers (N) and 10 CHF patients with a mercury-in-rubber strain gauge plethysmograph. CHF patients had a significantly lower VV[30] at rest and after intra-arterial phentolamine (2 mg) than normal subjects, suggesting that in these patients a state of peripheral venoconstriction existed (rest-N: 4.63+/-0.17, CHF: 1.7+/-0.23 ml/100 ml, P < 0.01; pre- and postphentolamine-N: 4.85+/-0.21 to 4.95+/-0.31, CHF: 2.26+/-0.29 to 2.68+/-0.38 ml/100 ml, P < 0.01). Of note is that alpha adrenergic blockade failed to increase VV[30] significantly in N, but did increase it in CHF (P < 0.05), suggesting that part of the decreased VV[30] in CHF in due to an augmented sympathoadrenal discharge. When sodium nitrite (30 mg) was given as a single intra-arterial injection before or after phentolamine or when given in four successive doses at 3-min intervals, the VV[30] of CHF patients was never increased to more than 3.62+/-0.42 ml/100 ml and was always less than N (P < 0.01). Importantly, VV[30] in CHF after these interventions was even significantly less than that of N before intervention (P < 0.05), suggesting that factors other than local active smooth muscle venoconstriction were operative in CHF to lower VV[30]. It is suggested that perhaps clinically undetectable edema and an elevated tissue pressure may account for these differences.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-13188821, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-13206455, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-13356407, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-13491697, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-13845819, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-14001742, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-14135505, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-14201541, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-14439148, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-4358202, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-5351327, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-5412982, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-5433751, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-5641631, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-5822592, http://linkedlifedata.com/resource/pubmed/commentcorrection/4847244-5903941
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-24
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1974
pubmed:articleTitle
The contribution of local factors to the elevated venous tone of congestive heart failure.
pubmed:publicationType
Journal Article, Comparative Study