|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1974-9-17
|
|
pubmed:abstractText |
Repeated voluntary consumption of cannabis in milk (approximately 8 mg per day for 15 days) produced in mice tolerance to the hypothermic effect of tritiated Delta(1)-tetrahydrocannabinol ([(3)H]-Delta(1)-THC; 2 mg/kg i.v.) but not to the effect of [(3)H]-Delta(1)-THC on immobility index. The development of tolerance was not accompanied by any detectable change in levels of radioactivity in the brain assigned to Delta(1)-THC or its metabolites. It was concluded that changes in metabolism or distribution of Delta(1)-THC are not responsible for tolerance at least to the hypothermic effect of Delta(1)-THC in mice.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0007-1188
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
49
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
373-5
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:4793443-Animals,
pubmed-meshheading:4793443-Body Temperature,
pubmed-meshheading:4793443-Body Temperature Regulation,
pubmed-meshheading:4793443-Brain,
pubmed-meshheading:4793443-Cannabis,
pubmed-meshheading:4793443-Depression, Chemical,
pubmed-meshheading:4793443-Drug Tolerance,
pubmed-meshheading:4793443-Male,
pubmed-meshheading:4793443-Mice,
pubmed-meshheading:4793443-Temperature,
pubmed-meshheading:4793443-Tetrahydrocannabinol,
pubmed-meshheading:4793443-Tritium
|
|
pubmed:year |
1973
|
|
pubmed:articleTitle |
Brain levels of delta1-tetrahydrocannabinol and its metabolites in mice tolerant to the hypothermic effect of delta1-tetrahydrocannabinol.
|
|
pubmed:publicationType |
Journal Article
|
