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pubmed:otherAbstract |
PIP: The serum ferroxidase activity and the iron mobilization of estrogens were studied in chickens and turkeys. Serum iron and copper were determined in 20 male chickens, 5 adult females (not laying), 12 laying chickens, 13 male turkeys, 5 adult females (not laying), and 4 laying turkeys. Serum iron and copper increased simultaneously during the laying period as a consequence of a higher estrogen level during this period. Evidence of this was obtained by injecting estradiol benzoate (3 mg estradiol, 3 times/week for 2 weeks) which produced a 6-fold increase of serum iron and copper. The levels dropped to base line values after a third week without treatment. A maximum ferroxidase activity was noted during the laying period representing a 20-fold incre ase while iron showed a 7-fold increase. 2 mg diethylstilbestrol/kg adm inistered to 6 immature pullets demonstrated an increase in the ferroxid ase activity with a peak at 36 hours and a peak of iron at 60 hours. Serum mare gonadotrophin caused a significant increase in ferroxidase activity by Day 14 (p less than .0001). These results suggest that the ferroxidase induction by exogenous estrogens or by endogenous estrogens is an identical effect.
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