Linked Life Data

478174

Source:http://linkedlifedata.com/resource/pubmed/id/478174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1979-11-21
pubmed:abstractText
The latency of onset and the duration of sleep induced by pentobarbital was studied in rats from 9 to 35 days of age, as well as in adult rats. Sleep latency was prolonged and sleep duration shortened with increasing age and maturation. Electrocorticographic changes after pentobarbital administration were studied in rats of 5-45 days of age and in adult rats. In rats 9 days of age or less the electrocorticogram manifested only depression of activity, whereas from the 12th day onward all characteristic barbiturate-induced phenomena were registered: spindles, slow waves, and isolated spikes with suppression of background activity. Spindles were the most conspicuous of the pentobarbital-induced phenomena and were the 1st to appear as a function of age, occurring only in the frontal areas of 12 days of age but in both frontal and occipital areas at 15 days of age. Frequency of the elements comprising spindles increased with from 2.5-3.5 c/sec in 12-day-old rats to 5-10 c/sec in adult animals. Barbiturate spindles could be used as a model for rhythmic thalamocortical phenomena even at early stages of development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0012-1630
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-25
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Ontogenetic development of pentobarbital-induced EEG pattern and sleeping time in rats.
pubmed:publicationType
Journal Article