Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1974-3-28
pubmed:abstractText
1. The intraperitoneal injection of N-methyl-N-nitrosourea (100mg/kg) caused a partial inhibition of protein synthesis in several organs of the rat, the maximum effect occurring after 2-3h. 2. In the liver the inhibition of protein synthesis was paralleled by a marked disaggregation of polyribosomes and an increase in ribosome monomers and ribosomal subunits. No significant breakdown of polyribosomes was found in adult rat brains although N-methyl-N-nitrosourea inhibited cerebral and hepatic protein synthesis to a similar extent. In weanling rats N-methyl-N-nitrosourea caused a shift in the cerebral polyribosome profile similar to but less marked than that in rat liver. 3. Reaction of polyribosomal RNA with N-[(14)C]methyl-N-nitrosourea in vitro did not lead to a disaggregation of polyribosomes although the amounts of 7-methylguanine produced were up to twenty times higher than those found after administration of sublethal doses in vivo. 4. It was concluded that changes in the polyribosome profile induced by N-methyl-N-nitrosourea may reflect the mechanism of inhibition of protein synthesis rather than being a direct consequence of the methylation of polyribosomal mRNA.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-14075106, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-14240664, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-14324825, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-4230610, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-4256414, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-4643764, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-4673570, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-4698302, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-4862936, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-4898286, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-4969994, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-5041565, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-5120304, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-5144850, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-5163160, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-5394503, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-5552389, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-5555565, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-5584005, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-5680613, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-5722690, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-5722691, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-5768434, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-5787640, http://linkedlifedata.com/resource/pubmed/commentcorrection/4774397-6068285
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:volume
136
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1973
pubmed:articleTitle
Inhibition of protein synthesis by N-methyl-N-nitrosourea in vivo.
pubmed:publicationType
Journal Article