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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1979-11-28
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pubmed:abstractText |
The AA in experiments performed on male rats treated with 0,5 mCi/kg of cycloheximide have observed an inhibition of liver protein degradation and have suggested two mechanism: 1) cycloheximide prevents the acute proteolytic response induced in fibroblast culture by exposure to serum-deficient media and in rat livers after perfusion probably by inhibiting the lysosomal - autophagic system, without modifications in total activity of lysosome proteinases. 2) It may be that protein degradation rate and level of lysosomal proteinases reinterrelated; the latter probably being a factor controlling the overall cell protein turnover rate.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0037-8771
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-8
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pubmed:dateRevised |
2007-10-17
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pubmed:meshHeading |
pubmed-meshheading:475921-Animals,
pubmed-meshheading:475921-Cathepsins,
pubmed-meshheading:475921-Cycloheximide,
pubmed-meshheading:475921-Fasting,
pubmed-meshheading:475921-Hydrolases,
pubmed-meshheading:475921-Liver,
pubmed-meshheading:475921-Lysosomes,
pubmed-meshheading:475921-Male,
pubmed-meshheading:475921-Organ Size,
pubmed-meshheading:475921-Proteins,
pubmed-meshheading:475921-Rats,
pubmed-meshheading:475921-Time Factors
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pubmed:year |
1979
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pubmed:articleTitle |
Inhibition of liver protein degradation in vivo by intensive treatment with cycloheximide.
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pubmed:publicationType |
Journal Article,
Comparative Study
|