Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5895
pubmed:dateCreated
1974-1-31
pubmed:abstractText
Seven types of digoxin 0.25 mg tablet in common use in the United Kingdom were administered to a total of 38 patients. Significant differences were found in the mean plasma digoxin levels and in the control of atrial fibrillation achieved with these brands. There was a close correlation between the dissolution rate of the tablets and the plasma digoxin levels. Measurement of in-vitro dissolution rate appears to be a valid method of ensuring that different tablets of digoxin are of equal efficacy. However, in some patients absorption of the drug is markedly sensitive to changes in dissolution rate and new pharmacopoeal standards should not be defined until very rapidly-dissolving formulations have been studied.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4758573-13525189, http://linkedlifedata.com/resource/pubmed/commentcorrection/4758573-4106706, http://linkedlifedata.com/resource/pubmed/commentcorrection/4758573-4115034, http://linkedlifedata.com/resource/pubmed/commentcorrection/4758573-4115048, http://linkedlifedata.com/resource/pubmed/commentcorrection/4758573-4115839, http://linkedlifedata.com/resource/pubmed/commentcorrection/4758573-4122564, http://linkedlifedata.com/resource/pubmed/commentcorrection/4758573-4123140, http://linkedlifedata.com/resource/pubmed/commentcorrection/4758573-4124293, http://linkedlifedata.com/resource/pubmed/commentcorrection/4758573-4261090, http://linkedlifedata.com/resource/pubmed/commentcorrection/4758573-4694690, http://linkedlifedata.com/resource/pubmed/commentcorrection/4758573-5121186, http://linkedlifedata.com/resource/pubmed/commentcorrection/4758573-5454321
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0007-1447
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
763-6
pubmed:dateRevised
2010-10-26
pubmed:meshHeading
pubmed:year
1973
pubmed:articleTitle
Therapeutic non-equivalence of digoxin tablets in the United Kingdom: correlation with tablet dissolution rate.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial