Linked Life Data

472640

Source:http://linkedlifedata.com/resource/pubmed/id/472640

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1979-10-17
pubmed:abstractText
The stereotyped development and the cellular kinetics of lung granulomas experimentally-induced in rabbits by an intravenous injection of the complete Freund adjuvant with addition of human gammaglobulin, were studied under the influence of hydrocortisone acetate, rifampicin, heparin and phenobarbital. As in a previous study using actinomycin and puromycin, the analysed drugs delayed up to inhibition (hydrocortisone) the development of lung granulomas which remained small, unfused, without epithelioidosis; the primary and secondary immune responses were more or less influenced up to their suppression. The delivery of macrophages was reduced by hydrocortisone, but enhanced by heparin and phenobarbital. The latter induced a persistent intragranulomatous granulocytosis, expressing the repair of decreased activities of dehydrogenases and especially of NADP-NADPH-oxidases. The action of these drugs was phasic, their intervention being active only during the cellular phase of granulomas; fibrillogenesis was influenced only indirectly. Extrapolation to humans of these results suggests the use of these drugs during the cellular phase of chronic pneumonitic lesions and suppression of the immune component of the inflammatory processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0377-1202
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-85
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:articleTitle
Morphogenesis and pathogenesis of chronic lung diseases. XVI. The influence of drugs on the stereotyped development and cellular kinetics of experimental lung granulomas.
pubmed:publicationType
Journal Article