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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1973-9-24
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pubmed:abstractText |
Serum gastrin was measured by radioimmunoassay in four patients with pernicious anaemia and four patients with the Zollinger-Ellison syndrome before and after the intravenous injection of 1 mg glucagon. Serum gastrin fell significantly in the patients with pernicious anaemia whilst in the patients with the Zollinger-Ellison syndrome there was a significant rise. Concomitant measurement of gastric acid output in one subject with the Zollinger-Ellison syndrome also showed a rise in acid output with glucagon. The reason for the paradoxical rise in gastrin in response to glucagon in the Zollinger-Ellison syndrome is unknown, but the response may provide a further diagnostic aid to this condition.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0017-5749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
459-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4719212-Aged,
pubmed-meshheading:4719212-Anemia, Pernicious,
pubmed-meshheading:4719212-Female,
pubmed-meshheading:4719212-Gastric Juice,
pubmed-meshheading:4719212-Gastrins,
pubmed-meshheading:4719212-Glucagon,
pubmed-meshheading:4719212-Humans,
pubmed-meshheading:4719212-Male,
pubmed-meshheading:4719212-Middle Aged,
pubmed-meshheading:4719212-Radioimmunoassay,
pubmed-meshheading:4719212-Secretory Rate,
pubmed-meshheading:4719212-Time Factors,
pubmed-meshheading:4719212-Zollinger-Ellison Syndrome
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pubmed:year |
1973
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pubmed:articleTitle |
Effect of glucagon on serum gastrin. II. Studies in pernicious anaemia and the Zollinger-Ellison syndrome.
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pubmed:publicationType |
Journal Article
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