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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1973-7-9
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pubmed:abstractText |
Highly purified inhibitor of the first component of complement (C?INH) was shown to inhibit the capacity of active Hageman factor fragments to initiate kinin generation, fibrinolysis, and coagulation. The inhibition of prealbumin Hageman factor fragments observed was dependent upon the time of interaction of the fragments with C?INH and not to an effect upon kallikrein or plasmin generated. The inhibition of the coagulant activity of the intermediate sized Hageman factor fragment by C?INH was not due to an effect on PTA or other clotting factors. The inhibition by C?INH of both the prealbumin and intermediate sized Hageman factor fragments occurred in a dose response fashion. The C?INH did not appear to be consumed when the activity of the Hageman factor fragments was blocked, although the fragments themselves could no longer be recovered functionally or as a protein on alkaline disc gel electrophoretic analysis. These results suggest that the C?INH may have an enzymatic effect on the fragments or that an additional site on C?INH is involved in C? inactivation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-13517252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-13739760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-14005494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-14245160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-14450472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-4107267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-4113723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-4178758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-4241814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-4251126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-4264575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-4956917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-4972183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-5033664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-5435787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-5470521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-5475635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4703226-5477337
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1402-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4703226-Blood Coagulation,
pubmed-meshheading:4703226-Chromatography, Affinity,
pubmed-meshheading:4703226-Chromatography, Gel,
pubmed-meshheading:4703226-Complement Inactivator Proteins,
pubmed-meshheading:4703226-Dose-Response Relationship, Drug,
pubmed-meshheading:4703226-Electrophoresis, Disc,
pubmed-meshheading:4703226-Factor XII,
pubmed-meshheading:4703226-Fibrinolysis,
pubmed-meshheading:4703226-Humans,
pubmed-meshheading:4703226-Kallikreins,
pubmed-meshheading:4703226-Kinetics,
pubmed-meshheading:4703226-Kinins
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pubmed:year |
1973
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pubmed:articleTitle |
Inhibition by C1INH of Hagemann factor fragment activation of coagulation, fibrinolysis, and kinin generation.
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pubmed:publicationType |
Journal Article,
In Vitro
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