| pubmed-article:4693654 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4693654 | lifeskim:mentions | umls-concept:C0027697 | lld:lifeskim |
| pubmed-article:4693654 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:4693654 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:4693654 | lifeskim:mentions | umls-concept:C0853888 | lld:lifeskim |
| pubmed-article:4693654 | lifeskim:mentions | umls-concept:C0033453 | lld:lifeskim |
| pubmed-article:4693654 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:4693654 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:4693654 | pubmed:dateCreated | 1973-5-18 | lld:pubmed |
| pubmed-article:4693654 | pubmed:abstractText | Membranoproliferative nephritis in children is frequently associated with a hypocomplementemia produced at least in part by C3 breakdown mediated by a circulating anticomplementary factor known as C3 nephritic factor (C3NeF). C3 breakdown by this factor in vitro requires the presence of a pseudoglobulin cofactor and magnesium. The present study provides evidence that properdin factor B (C3 proactivator) is activated in the nephritic factor reaction and is the direct mediator of C3 breakdown by C3NeF. Depletion of factor B from mixtures of normal human serum (NHS) and plasma from a patient with membranoproliferative nephritis (MPP), either by heating or by immune equivalence absorption, blocks C3 breakdown by C3NeF. Addition of purified factor B to these mixtures restores the anticomplementary effect. When purified factor B is added to mixtures of MPP and purified C3, breakdown also occurs. Associated with the C3 breakdown is a change in the electrophoretic mobility of factor B from the beta to the gamma position, a shift which has been associated with cleavage activation of the molecule. Further, serum factor B levels are often low in patients with membranoproliferative nephritis and bear a rough inverse correlation with C3NeF levels. It thus appears that factor B is the previously described heat-labile C3NeF cofactor. Whether the C3NeF reaction proceeds via a pathway comparable to that activated by the cobra venom factor or via that activated by zymosan or inulin cannot be determined from the present data. | lld:pubmed |
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| pubmed-article:4693654 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4693654 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4693654 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:4693654 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4693654 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:4693654 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:4693654 | pubmed:author | pubmed-author:AndrewGG | lld:pubmed |
| pubmed-article:4693654 | pubmed:author | pubmed-author:DavisN CNC | lld:pubmed |
| pubmed-article:4693654 | pubmed:author | pubmed-author:WestC DCD | lld:pubmed |
| pubmed-article:4693654 | pubmed:author | pubmed-author:ForristalJJ | lld:pubmed |
| pubmed-article:4693654 | pubmed:author | pubmed-author:RuleyE JEJ | lld:pubmed |
| pubmed-article:4693654 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4693654 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:4693654 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4693654 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4693654 | pubmed:pagination | 896-904 | lld:pubmed |
| pubmed-article:4693654 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4693654 | pubmed:year | 1973 | lld:pubmed |
| pubmed-article:4693654 | pubmed:articleTitle | Hypocomplementemia of membranoproliferative nephritis. Dependence of the nephritic factor reaction on properdin factor B. | lld:pubmed |
| pubmed-article:4693654 | pubmed:publicationType | Journal Article | lld:pubmed |
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