Linked Life Data

46922

Source:http://linkedlifedata.com/resource/pubmed/id/46922

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1975-6-12
pubmed:abstractText
Immunization of rabbits with carboxyfentanyl-bovine gamma-globulin conjugate induced antibodies of high titers capable of binding with fentanyl. The antibodies exhibited high average association constants (approximately 1 times 10-7 liter/mol) and were highly specific to fentanyl since no cross-reactivity was observed for a variety of test compounds including other opiates and analgesics. Serological cross-reactivity was observed only for chemicals representing various portions of the fentanyl molecule. These high-affinity, highly selective antibodies have been successfully employed in a radioimmunoassay for fentanyl. Serum concentrations of fentanyl, after administration of 100 and 21 mug/kg/ i.v. in dogs, were determined by this radioimmunoassay. The specificity of these antibodies as compared with the specificity of the pharmacological (opiate) receptor is also discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
192
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
489-96
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Antibodies to fentanyl.
pubmed:publicationType
Journal Article