|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1975-6-12
|
|
pubmed:abstractText |
An inhibitor of histamine release was found to be associated with the human eosinophilic leukocyte. This eosinophil-derived inhibitor (EDI) was released from eosinophil-rich fractions upon sonication or interaction with immune reactants (specific allergens or anti-IgE). EDI was found to exert its inhibitory action at the target cell level by increasing the intracellular levels of cyclic-AMP. Preliminary electron microscopic studies show the presence of IgE on the eosinophilic leukocyte and it is suggested that the allergen or anti-IgE-induced release of EDI might be due to a direct interaction of these immune reactants with the eosinophil-bound IgE antibody. The results also suggest that by virtue of liberating a histamine release inhibitor such as EDI, the eopsinophil assumes a modulating role in the allergic inflammatory reaction.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
114
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1379-88
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:46900-Animals,
pubmed-meshheading:46900-Antibodies,
pubmed-meshheading:46900-Antigen-Antibody Reactions,
pubmed-meshheading:46900-Cell Separation,
pubmed-meshheading:46900-Cyclic AMP,
pubmed-meshheading:46900-Eosinophils,
pubmed-meshheading:46900-Ferritins,
pubmed-meshheading:46900-Fluorometry,
pubmed-meshheading:46900-Goats,
pubmed-meshheading:46900-Histamine,
pubmed-meshheading:46900-Histamine Release,
pubmed-meshheading:46900-Humans,
pubmed-meshheading:46900-Hypersensitivity,
pubmed-meshheading:46900-Immunoglobulin E,
pubmed-meshheading:46900-Leukocyte Count,
pubmed-meshheading:46900-Leukocytes,
pubmed-meshheading:46900-Microscopy, Electron,
pubmed-meshheading:46900-Neutrophils,
pubmed-meshheading:46900-Sonication,
pubmed-meshheading:46900-Tritium
|
|
pubmed:year |
1975
|
|
pubmed:articleTitle |
Role of the eosinophil in the allergic reactions. I. EDI-an eosinophil-derived inhibitor of histamine release.
|
|
pubmed:publicationType |
Journal Article
|
