Linked Life Data

46680

Source:http://linkedlifedata.com/resource/pubmed/id/46680

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1975-5-21
pubmed:abstractText
The distribution pattern of oestradiol in ovariectomized rats as a function of time has been studied following intravenous adminstration of the tritiated hormone. Oestrogen specific binding with limited capacity was observed in the uterus, vagina, anterior pituitary, adrenals, preoptic area, hypothalamus, amygdala, septum and tractus diagonalis. Maximal uptake of oestradiol in the pituitary occurred within 5 min, in the uterus 60 min after injection, and remained almost unchanged at this level for more than two hours. The binding capacity per mg tissue decreased in the order pituitary, uterus, vagina, preoptic area, adrenals, hypothalamus, amygdala, spetum and tractus diagonalis. The hormone concentration in these tissues one hour after (3H)oestradiol injection was lowered by previous administration of ethinodiol, norethinodrel, lynestrenol and norethindrone, whereas medroxyprogesterone, chlormadinone, megestrol and methyllynestrenol had no effect. The same results were obtained, when instead of the steroid alcohols the corresponding acetate esters were administered. For norgestrel, oestrenol and nortestosterone the effect in the dose range studied was limited to the pituitary and preoptic area. For lynestrenol the inhibition of oestradiol binding in the target tissues was almost the same when the progestin was given 60 and 5 min before oestradiol, whereas in the case of administration 30 min after oestradiol no inhibition was observed. The reduction of oestrogen binding appeared to be dose-dependent, but the dose required to obtain a certain effect for the uterus was four times as high as for the pituitary. Discrepancies between previous studies and the implications of the present findings for the mechanism of action of ovulation inhibition by these progestins are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0001-5598
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-64
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:46680-Adrenal Glands, pubmed-meshheading:46680-Animals, pubmed-meshheading:46680-Binding Sites, pubmed-meshheading:46680-Brain, pubmed-meshheading:46680-Castration, pubmed-meshheading:46680-Chlormadinone Acetate, pubmed-meshheading:46680-Depression, Chemical, pubmed-meshheading:46680-Estradiol, pubmed-meshheading:46680-Ethynodiol Diacetate, pubmed-meshheading:46680-Female, pubmed-meshheading:46680-Lynestrenol, pubmed-meshheading:46680-Medroxyprogesterone, pubmed-meshheading:46680-Megestrol, pubmed-meshheading:46680-Nandrolone, pubmed-meshheading:46680-Norethindrone, pubmed-meshheading:46680-Norethynodrel, pubmed-meshheading:46680-Ovary, pubmed-meshheading:46680-Pituitary Gland, Anterior, pubmed-meshheading:46680-Progesterone Congeners, pubmed-meshheading:46680-Rats, pubmed-meshheading:46680-Receptors, Cell Surface, pubmed-meshheading:46680-Stimulation, Chemical, pubmed-meshheading:46680-Time Factors, pubmed-meshheading:46680-Uterus, pubmed-meshheading:46680-Vagina
pubmed:year
1975
pubmed:articleTitle
Interaction of contraceptive progestins and related compounds with the oestrogen receptor. Part I: Effect on (3H)oestradiol distribution pattern in the ovariectomized rat.
pubmed:publicationType
Journal Article, Comparative Study