|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1973-4-3
|
|
pubmed:abstractText |
1. The metabolism of sodium cortisone 21-[(35)S]sulphate was investigated in rats. 2. Quantitative and qualitative experiments showed that substantial amounts of (35)SO(4) (2-) appeared in the urine of free-ranging rats receiving the ester. 3. Whole-body radioautograms indicated considerable biliary elimination of (35)S and also pointed to the liver as the site of metabolism. 4. When female rats with bile-duct cannulae received sodium cortisone 21-[(35)S]sulphate approx. 70% of the dose appeared in the bile as a doubly conjugated steroid (metabolite I). This metabolite was identified as 3alpha-(beta-d-glucopyranuronosido)- 17alpha-hydroxy-21-[(35)S]sulpho-oxy-5alpha-pregnane-11,20-dione. 5. When metabolite I was administered to a rat with a bile-duct cannula 90% of the dose appeared in the bile unchanged. After the administration (intraperitoneally or orally) of metabolite I to free-ranging rats considerable amounts of (35)SO(4) (2-) appeared in the urine. 6. The route by which (35)SO(4) (2-) might be produced from cortisone [(35)S]sulphate in free-ranging animals is discussed.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-13058425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-13203055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-13208273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-13239580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-13293150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-13459921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-13522654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-13535577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-13614433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-13876933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-14332092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-14484190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-16748495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-16748876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-16748925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-4226722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-4245954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-5583990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-5965955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-6026366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4651133-6065964
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0264-6021
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
127
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
661-8
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:4651133-Animals,
pubmed-meshheading:4651133-Autoradiography,
pubmed-meshheading:4651133-Bile,
pubmed-meshheading:4651133-Chromatography, Paper,
pubmed-meshheading:4651133-Cortisone,
pubmed-meshheading:4651133-Electrophoresis, Paper,
pubmed-meshheading:4651133-Female,
pubmed-meshheading:4651133-Liver,
pubmed-meshheading:4651133-Male,
pubmed-meshheading:4651133-Rats,
pubmed-meshheading:4651133-Steroids,
pubmed-meshheading:4651133-Sulfates,
pubmed-meshheading:4651133-Sulfur Isotopes
|
|
pubmed:year |
1972
|
|
pubmed:articleTitle |
The metabolism of sodium cortisone 21-( 35 S)sulphate in the rat.
|
|
pubmed:publicationType |
Journal Article
|
