pubmed:abstractText |
Delayed-type hypersensitivity to methylated bovine serum albumin (MBSA), as induced by 6-hydroxydopamine (6-OHDA) was studied in chemically sympathectomized mice. Footpad reaction at 48 h after challenge injection of MBSA was suppressed with doses ranging from 10--300 mg/kg. 6-OHDA was neither cytotoxic to peritoneal macrophages nor was the function of immunoglobulin mediated phagocytosis suppressed. Thus, the suppression of delayed-type hypersensitivity may be attributed to interference with T-cell function.
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