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rdf:type |
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lifeskim:mentions |
umls-concept:C0014834,
umls-concept:C0017337,
umls-concept:C0030685,
umls-concept:C0031298,
umls-concept:C0040649,
umls-concept:C0391871,
umls-concept:C0596963,
umls-concept:C0599945,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1549081,
umls-concept:C1692758,
umls-concept:C1963578
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pubmed:issue |
6
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pubmed:dateCreated |
1974-9-17
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pubmed:abstractText |
The induction of lambda prophage provokes the constitutive expression of the adjacent gal operon in E. coli. This "escape synthesis" can result from transcription that initiates at a phage promoter and extends into the gal operon. The effect requires the product of the lambda gene N. N-mediated transcription not only fails to terminate at the prophage-bacterial junction and at the ends of bacterial operons, but ignores termination signals caused by polar insertions or ochre mutations within gal. Suppression of polarity by N-function is a cis-effect; only transcription initiated at the phage promoter is influenced. We propose that the transcription complex is influenced by N-product to become termination-resistant at a site in the phage genome (juggernaut model). This site appears to be at or near the phage promoter.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-13690195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-14062651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-14102193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-16590796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4315149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4324343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4346883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4348358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4353625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4556510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4567396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4568728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4686983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4883532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4896247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4902144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4915096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4939778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4943550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-4966929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-5040359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-5246538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-5331913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-5332079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-5338525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-5475574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-5637199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-5719216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4601822-5812352
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2534-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4601822-Chromosome Mapping,
pubmed-meshheading:4601822-Chromosomes, Bacterial,
pubmed-meshheading:4601822-Coliphages,
pubmed-meshheading:4601822-DNA Viruses,
pubmed-meshheading:4601822-Escherichia coli,
pubmed-meshheading:4601822-Galactose,
pubmed-meshheading:4601822-Genes, Regulator,
pubmed-meshheading:4601822-Lysogeny,
pubmed-meshheading:4601822-Mutation,
pubmed-meshheading:4601822-Operon,
pubmed-meshheading:4601822-Transcription, Genetic
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pubmed:year |
1974
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pubmed:articleTitle |
Release of polarity in Escherichia coli by gene N of phage lambda: termination and antitermination of transcription.
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pubmed:publicationType |
Journal Article
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