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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1974-4-4
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pubmed:abstractText |
The data presented in this paper support the hypothesis that unresponsiveness to autologous thyroglobulin (Tg) exists in the T cells and responsiveness exists in the B cells. Such a conclusion is based on the results of antigen-binding studies where few, if any, thymocytes recognized syngeneic Tg. Comparable numbers of antigen-binding lymphocytes for syngeneic Tg were found in the spleens of normal intact mice and of nude mice. The latter fact suggested that B cells exist which recognize self-constituents. From antigen-suicide experiments, a clearer picture of the susceptibility of B cells to iodinated self-antigen and of the obligatory role of antibody in the induction of lesions was developed. Only bone marrow cells (B cells) were affected by [(125)I]syngeneic Tg, in which case the incidence of lesions was diminished. From adoptive transfer experiments, the results demonstrate that unresponsiveness may be terminated by immunization with a mixture of heterologous (cross-reacting) Tg's. In this situation T cells are required since a B-cell reconstituted host failed to make antibody (plaque-forming cells) and to develop lesions. T cells in this form of an unresponsive state may recognize determinants on the heterologous Tg unrelated to autologous Tg and as such stimulate the normal complement of B cells to produce antibody that both reacts with autologous and heterologous Tg.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-13611294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-13699041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-13774132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-13957684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-14264273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-14330416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4103326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4119376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4119592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4121927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4160044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4170425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4187480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4192271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4192295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4240217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4262347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4565839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4920186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4934503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4983532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-4984124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-5064268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-5086522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-5166005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-5288821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-5475513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-5553717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-5723648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-5918139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4591173-6082462
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
643-60
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pubmed:dateRevised |
2010-6-22
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pubmed:meshHeading |
pubmed-meshheading:4591173-Animals,
pubmed-meshheading:4591173-Antibody Formation,
pubmed-meshheading:4591173-Antibody Specificity,
pubmed-meshheading:4591173-Autoantibodies,
pubmed-meshheading:4591173-Autoradiography,
pubmed-meshheading:4591173-B-Lymphocytes,
pubmed-meshheading:4591173-Bone Marrow,
pubmed-meshheading:4591173-Bone Marrow Cells,
pubmed-meshheading:4591173-Cattle,
pubmed-meshheading:4591173-Fluorescent Antibody Technique,
pubmed-meshheading:4591173-Goats,
pubmed-meshheading:4591173-Hemolytic Plaque Technique,
pubmed-meshheading:4591173-Horses,
pubmed-meshheading:4591173-Immune Sera,
pubmed-meshheading:4591173-Immunization,
pubmed-meshheading:4591173-Immunoglobulin Fab Fragments,
pubmed-meshheading:4591173-Injections, Intraperitoneal,
pubmed-meshheading:4591173-Iodine Radioisotopes,
pubmed-meshheading:4591173-Isotope Labeling,
pubmed-meshheading:4591173-Mice,
pubmed-meshheading:4591173-Mice, Inbred Strains,
pubmed-meshheading:4591173-Nitrogen,
pubmed-meshheading:4591173-Rabbits,
pubmed-meshheading:4591173-Spleen,
pubmed-meshheading:4591173-T-Lymphocytes,
pubmed-meshheading:4591173-Thymus Gland,
pubmed-meshheading:4591173-Thyroglobulin,
pubmed-meshheading:4591173-Thyroid Gland,
pubmed-meshheading:4591173-Thyroiditis
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pubmed:year |
1974
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pubmed:articleTitle |
Roles of T and B lymphocytes in the termination of unresponsiveness to autologous thyroglobulin in mice.
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pubmed:publicationType |
Journal Article
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