Linked Life Data

458490

Source:http://linkedlifedata.com/resource/pubmed/id/458490

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1979-9-27
pubmed:abstractText
Reinvestigation of the previously reported toxicity of saturated fat on weanling mice has shown rac-1(3)-palmitoyl glycerol to be a more potent toxic agent than free palmitic acid when fed as the sole source of dietary fat. As shown before, protection against this toxicity can be afforded by the addition of 2 to 4% safflower oil. We have now shown that if the rac-1(3)-palmitoyl glycerol is acetylated the toxicity is much less. The protective effect of diacetyl rac-1(3)-palmitoyl glycerol cannot be totally ascribed either to the presence of acetate itself or to the blocking of the free hydroxyls of palmitoyl glycerol by acylation. In vivo absorption studies coupled with in vitro experiments with pancreatic lipase suggest that the major protective effects result from increased lipolysis of the acylated palmitoyl glycerol, causing conversion to the less toxic free palmitic acid.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1358-67
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Toxicity of rac-1(3)-palmitoyl glycerol in weanling mice.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.