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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1973-10-9
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pubmed:abstractText |
The ability of bacterial lipopolysaccharides to induce lymphocyte mitogenesis and to act as an adjuvant of antibody formation was attributable to the lipid-A region of the molecule. Measured by induction of DNA synthesis, lipid A was mitogenic for bone marrow-derived lymphocytes obtained from spleens of congenitally athymic mice but not for thymocytes obtained from thymuses of normal mice. Adjuvanticity was demonstrated by the ability of lipid A to convert a tolerogenic regimen of antigen into one eliciting an immune response and by its ability to markedly enhance the antibody response to a weak antigen.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-13286429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-13724354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-13957684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-14139023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-14265747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-16557702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-17842788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-4103727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-4108698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-4120288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-4170425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-4555121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-4557773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-4559167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-4563346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-4567119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-4874538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-4928750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-4929657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-4944989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-5010393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-5023169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-5069711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-5285341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-5804498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-5924622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-5926455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4579014-6034749
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2129-33
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:4579014-Adjuvants, Immunologic,
pubmed-meshheading:4579014-Animals,
pubmed-meshheading:4579014-Antibody Formation,
pubmed-meshheading:4579014-B-Lymphocytes,
pubmed-meshheading:4579014-Escherichia coli,
pubmed-meshheading:4579014-Immune Tolerance,
pubmed-meshheading:4579014-Immunization,
pubmed-meshheading:4579014-Lipopolysaccharides,
pubmed-meshheading:4579014-Lymphocyte Activation,
pubmed-meshheading:4579014-Mice,
pubmed-meshheading:4579014-Mice, Inbred A,
pubmed-meshheading:4579014-Mitogens,
pubmed-meshheading:4579014-Polysaccharides, Bacterial,
pubmed-meshheading:4579014-Salmonella,
pubmed-meshheading:4579014-Serum Albumin, Bovine,
pubmed-meshheading:4579014-Structure-Activity Relationship,
pubmed-meshheading:4579014-T-Lymphocytes
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pubmed:year |
1973
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pubmed:articleTitle |
Relationship of the structure of bacterial lipopolysaccharides to its function in mitogenesis and adjuvanticity.
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pubmed:publicationType |
Journal Article
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