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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1973-5-15
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pubmed:abstractText |
Some patients with the Zollinger-Ellison syndrome appear to have hypergastrinaemia and hyperplasia of the antral G cells but no tumour. This subgroup has been classified as Zollinger-Ellison syndrome type 1. We have treated such a patient by vagotomy and antrectomy, the fasting plasma gastrin and acid secretion subsequently returning to normal.A 17-year-old male had a four-year history of duodenal ulcer. Gastric secretion tests showed acid hypersecretion. Fasting plasma gastrin was 8350 pg/ml (normal 50-170 pg/ml). At laparotomy duodenal ulceration was confirmed but no pancreatic or other tumours were found. Truncal vagotomy and antrectomy was performed with distal pancreatectomy. Immunofluorescent staining showed hyperplasia of G cells in the resected antrum but a normal pancreas and duodenum. Six months after operation he was symptom free and acid secretion was reduced by 92%. The fasting plasma gastrin at two months was <50 pg/ml. These findings suggest that type 1 Zollinger-Ellison syndrome may be a clinical entity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-13259432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-14157455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-14392240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-4104174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-4176663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-4185638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-4187889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-4191046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-4300127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-4560738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-4905168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-4917502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-5001662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-5139116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4571070-5157133
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0017-5749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
25-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4571070-Adolescent,
pubmed-meshheading:4571070-Duodenal Ulcer,
pubmed-meshheading:4571070-Fluorescent Antibody Technique,
pubmed-meshheading:4571070-Gastric Juice,
pubmed-meshheading:4571070-Gastrins,
pubmed-meshheading:4571070-Humans,
pubmed-meshheading:4571070-Hyperplasia,
pubmed-meshheading:4571070-Islets of Langerhans,
pubmed-meshheading:4571070-Male,
pubmed-meshheading:4571070-Microscopy, Electron,
pubmed-meshheading:4571070-Pancreas,
pubmed-meshheading:4571070-Pyloric Antrum,
pubmed-meshheading:4571070-Vagotomy,
pubmed-meshheading:4571070-Zollinger-Ellison Syndrome
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pubmed:year |
1973
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pubmed:articleTitle |
Zollinger-Ellison syndrome type 1: clinical and pathological correlations in a case.
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pubmed:publicationType |
Journal Article
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