Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1973-5-4
pubmed:abstractText
From Escherichia coli strain K28, which is temperature sensitive for growth because of a mutation in its seryl-transfer ribonucleic acid (tRNA) synthetase gene (serS), temperature-resistant mutants were selected which were found to have a fivefold higher level of seryl-tRNA synthetase than the parent strain. The "high-level" character was found to be genetically stable and is due to a mutation in a locus denoted serO. This locus was found to be very closely linked to serS on the genetic map, and the relative gene order was concluded to be serS-serO-serC. In a serO(-) strain, the normal dependence of seryl-tRNA synthetase (SerRS) activity on changes of exogenous serine concentration was not observed. In a stable heterozygous merodiploid, the serO(-) mutation is still expressed, i.e., it is cis dominant. These results strongly suggest that serO is an operator site involved in the control of the serS gene.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-14338232, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-17842790, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-4332769, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-4333605, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-4551738, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-4568765, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-4570768, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-4870861, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-4896351, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-4898984, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-4918631, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-4928008, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-4929885, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-4933418, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-4934072, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-4941558, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-5342516, http://linkedlifedata.com/resource/pubmed/commentcorrection/4570769-5401233
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-9193
pubmed:author
pubmed:issnType
Print
pubmed:volume
113
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1096-103
pubmed:dateRevised
2010-9-10
pubmed:meshHeading
pubmed:year
1973
pubmed:articleTitle
Isolation and characterization of a regulatory mutant of an aminoacyl-transfer ribonucleic acid synthetase in Escherichia coli K-12.
pubmed:publicationType
Journal Article