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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1973-2-15
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pubmed:abstractText |
A temperature-sensitive mutant of Escherichia coli in which the synthesis of l-arabinose isomerase is blocked during growth at 42 C was found to possess the following properties. (i) The mutation occurred in the structural gene for the isomerase, gene araA. (ii) During growth at elevated temperatures the mutant accumulates a product which is a precursor to the active enzyme. (iii) The precursor produced at 42 C is slowly converted to active enzyme at 28 C in the absence of protein and ribonucleic acid synthesis. It is concluded that the mutation results in a change in the structure of isomerase which causes formation of active enzyme to be thermolabile at a step beyond the level of translation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-13696894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-13890280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-14077500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-14463540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-4330550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-4330551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-4553005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-4892369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-4894687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-4896751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-4920896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-4936722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-4941555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-5321403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-5340694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4565537-5541001
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
112
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1247-53
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4565537-Arabinose,
pubmed-meshheading:4565537-Bacterial Proteins,
pubmed-meshheading:4565537-Cell-Free System,
pubmed-meshheading:4565537-Chloramphenicol,
pubmed-meshheading:4565537-Enzyme Precursors,
pubmed-meshheading:4565537-Escherichia coli,
pubmed-meshheading:4565537-Genes,
pubmed-meshheading:4565537-Genetic Complementation Test,
pubmed-meshheading:4565537-Hot Temperature,
pubmed-meshheading:4565537-Isomerases,
pubmed-meshheading:4565537-Mutation,
pubmed-meshheading:4565537-Phosphotransferases,
pubmed-meshheading:4565537-RNA, Bacterial,
pubmed-meshheading:4565537-Stereoisomerism,
pubmed-meshheading:4565537-Transduction, Genetic
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pubmed:year |
1972
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pubmed:articleTitle |
L-arabinose isomerase formation in a conditional mutant of gene araA of Escherichia coli B-r.
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pubmed:publicationType |
Journal Article
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