Linked Life Data

4559464

Source:http://linkedlifedata.com/resource/pubmed/id/4559464

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1972-10-5
pubmed:abstractText
When a BCG strain is maintained by serial subcultures for several years, a change in its genetic properties may occur spontaneously. Such a change occurred in a strain maintained in the Norwegian State BCG Laboratory for 11 years. When received from Sweden in 1953, the strain was sensitive to the main tuberculostatics. However, in 1964, by mere chance, it was found to have become resistant to isoniazid. An examination of extant samples from the batches of freeze-dried vaccine produced during the period 1953-64 enabled the time and speed of the change to be determined. Although an alteration in drug sensitivity may not be harmful, it could cause a loss in the protective potency of a vaccine in man. It was to safeguard against this danger that the system of serial subcultures was discontinued and the seed lot system adopted, in accordance with WHO requirements.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0042-9686
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
503-7
pubmed:dateRevised
2010-10-26
pubmed:meshHeading
pubmed:year
1972
pubmed:articleTitle
Drug resistance in the Swedish/Norwegian BCG strain.
pubmed:publicationType
Journal Article