Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1974-2-12
pubmed:abstractText
The synthetic single- and double-stranded polynucleotides, poly I, poly C, and poly I.C, were shown to induce thymidine incorporation in six inbred strains of murine spleen cells. This stimulation was shown to be secondary to B-cell activation and not due to contamination of the polynucleotides with bacterial lipopolysaccharide (LPS). The ability of poly I.C to act as a B-cell mitogen, in addition to its behavior as a thymic-independent antigen, suggested that these two phenomena may be related. The similarity of the molecular structure of poly I.C to LPS, a material which also acts as a thymic-independent antigen and a B-cell mitogen, supports the hypothesis that the polyvalent nature of these materials accounts for their functional interaction with murine B cells.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-14193155, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-14207060, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4104294, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4116319, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4120225, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4120290, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4121424, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4123830, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4129423, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4144341, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4171947, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4193824, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4392631, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4392713, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4395114, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4403476, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4501342, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4504210, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4540021, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4540898, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4541325, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4559167, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4559170, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4561471, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4563346, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4563347, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4571328, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4577879, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4579014, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4588912, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4594974, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4695475, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4904563, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4941003, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4942636, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-4944989, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-5010393, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-5117671, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-5233831, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-5312420, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-5360538, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-5495449, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-5547300, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-5553718, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-5762050, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-5802680, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-5802681, http://linkedlifedata.com/resource/pubmed/commentcorrection/4543458-5805520
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
138
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1545-63
pubmed:dateRevised
2010-6-22
pubmed:meshHeading
pubmed:year
1973
pubmed:articleTitle
Specific murine B-cell activation by synthetic single-and double-stranded polynucleotides.
pubmed:publicationType
Journal Article