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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1973-8-6
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pubmed:abstractText |
7S anti-IgGs were isolated from four rabbit antistreptococcal antisera by the use of immunoabsorbent columns. The isolated proteins were of restricted molecular heterogeneity; they formed a monodisperse band on microzone electrophoresis and had a limited number of light chain bands when analyzed on urea polyacrylamide gel. The binding site of the 7S anti-IgGs was detected in the F(ab')(2) portion of the molecule. The binding site has antibody specificity for the Fc portion of IgG. For one 7S anti-IgG the combining site on the Fc portion could further be defined. A pepsin fragment of Fc, described as Pep-III', was a potent inhibitor of the coprecipitation of 7S anti-IgG with antigen-antibody complexes. An idiotypic cross-reaction was detected between the 7S and 19S anti-IgGs isolated from the same rabbit with anti-idiotype sera prepared in guinea pigs. This idiotypic specificity was not detected in the 7S anti-IgGs of 20 other rabbits.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-13754097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-13940587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-14427334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-19867369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-4098822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-4104426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-4106969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-4160396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-4176226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-4183706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-4185249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-4193453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-4403474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-4956917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-4959487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-4988920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-4999997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-5806584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4541124-6056841
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1354-68
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pubmed:dateRevised |
2010-9-13
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pubmed:meshHeading |
pubmed-meshheading:4541124-Animals,
pubmed-meshheading:4541124-Antibodies, Anti-Idiotypic,
pubmed-meshheading:4541124-Antigen-Antibody Complex,
pubmed-meshheading:4541124-Bacterial Vaccines,
pubmed-meshheading:4541124-Chromatography,
pubmed-meshheading:4541124-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:4541124-Immune Sera,
pubmed-meshheading:4541124-Immunochemistry,
pubmed-meshheading:4541124-Immunoglobulin G,
pubmed-meshheading:4541124-Immunoglobulin M,
pubmed-meshheading:4541124-Isoantigens,
pubmed-meshheading:4541124-Precipitin Tests,
pubmed-meshheading:4541124-Rabbits,
pubmed-meshheading:4541124-Radioimmunoassay,
pubmed-meshheading:4541124-Streptococcus
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pubmed:year |
1973
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pubmed:articleTitle |
Isolation and immunochemical characterization of rabbit 7S anti-IgG with restricted heterogeneity.
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pubmed:publicationType |
Journal Article
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